Web23 giu 2006 · Thus, Arg248 residues, embracing the DNA from the minor groove side, support the integrity and stability of the core dimers bound to their DNA half-sites. Mutations in this codon (being one of the six p53 hotspots) to Gln248 or Trp248 that are highly abundant in human cancer would disrupt the integrity of the core dimers bound to DNA, … WebIn the first case, family history was uneventful and the mutation was not found in either of the parents. The second patient, with a family history suggestive of LFS, unexpectedly resulted as a carrier of the mosaic mutation c.742=/C>T p.(Arg248=/Trp). The allele frequency was 26% in normal tissues and 42-77% in tumor specimens.
Arginine methylation of FOXO transcription factors inhibits their ...
Web28 ago 2024 · Experimental studies have shown that this missense change affects TP53 function (PMID: 17606709, 20128691, 21343334). This variant disrupts the p.Arg248 … Web26 mar 2015 · It is interesting to note that constricted C1′–C1′ distances naturally lead to a narrowed minor groove of the bp which can result in favorable electrostatic interactions through minor groove recognition as observed for example with Arg248 in the structure of the p53-DNA complex (17, 79). It is also important to note that DNA bending does ... gumball puberty episode
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Web24 ott 2008 · We demonstrate that PRMT1 methylates FOXO1 primarily at Arg248 and Arg250 that are conserved within the consensus Akt phosphorylation motif. This arginine methylation directly abrogates Akt-induced phosphorylation of FOXO1 at Ser253, which in turn results in increased nuclear localization, and inhibition of subsequent degradation. Webru14o2 arg248`nh1 2.8712 157.9147 48.13714 leu249`o ru15n3 2.9875 159.321 72.32 rrm ru15o2 val251`n 3.1068 150.8526 54.84 ru15o2p arg261`nh1 2.8527 151.7637 20.11714 … Web27 gen 2024 · Accordingly, in a coactivator recruitment assay, saroglitazar activated PPARα-LBD and PPARγ-LBD but not PPARδ-LBD, whereas glycine substitution of either Trp228, Arg248, or both of PPARδ-LBD conferred saroglitazar concentration-dependent activation. gumball price back in the day