Cdh16-cre

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August undefined, 2024

WebOct 5, 2024 · To explore the function of CDK12 in the kidney, we generated a novel CDK12 flox/flox line harboring loxP sites flanking exon 4 of the Cdk12 gene. By breeding with cdh16-Cre transgene mice, in which Cre expression is limited to the renal tubules, including Bowman’s capsule, proximal tubule, loop of Henle, distal tubule, and the collecting duct, … WebPkd1 fl/fl; Cdh16-Cre mice were generated by crossing Pkd1 fl/fl mice with Cdh16-Cre mice. Pkd1 fl/fl; Cdh16-Cre mice were then crossed with A-CREB transgenic mice. Both sexes were used in the kidney-specific mouse model, and mice were euthanized at P7. Five pairs of kidneys were collected for tissue section analysis and the rest were used for ...

CDH16 Gene - GeneCards CAD16 Protein CAD16 …

WebEZH2 conditional knockout mice were generated by breeding our EZH2 fl/fl mice with Cdh16-Cre mice to obtain Cdh16-Cre +: EZH2 fl/fl mice (EZH2-cKO) and Cdh16-Cre −: EZH2 fl/fl mice (EZH2-WT). Our data showed that EZH2-cKO or inhibition of EZH2 with 3-DZNep significantly alleviated kidney damage and reduced serum creatinine and BUN in … WebJun 22, 2024 · Cdh16, also known as kidney specific protein (Ksp), is expressed in kidney distal nephrons including the loop of Henle, distal convoluted tubules, and collecting … tara jobling pen

Tubular-specific CDK12 knockout causes a defect in

WebCre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may … Please use this form to enter mouse-related technical questions, comments, … WebThe transgene consists of a tamoxifen-inducible cre recombinase driven by the 2.3-kb mouse Col1a1, collagen, type I, alpha 1, promoter. The transgene insert contains a fusion product involving cre recombinase and a mutant form of the mouse estrogen receptor ligand binding domain. The mutant mouse estrogen receptor does not bind natural ligand ... WebMay 1, 2024 · FXR knockout (KO), Kap-Cre, Cdh16-Cre, and FXR flox/flox mice were purchased from the Jackson Laboratory. The details of animal studies are provided in the Supplementary ... we crossed FXR flox/flox mice (FXR f/f) with Kap-Cre expressing mice to generate PT-FXR-KO mice (Supplementary Figure S17A and B), which allows the … t-ara jiyeon scandal

Tg (Cdh16-cre/ERT2)F427Djmp Transgene Detail MGI Mouse …

WebMETHODS@#Cdh16-Cre tool mice and Kindlin-2flox/flox mice were used to construct the mouse model of uterus specific knockout of Kindlin-2, and the effects of Kindlin-2 deletion on uterine development and reproduction capacity of female mice were observed. WebTo study these effects, we generated three lines of kidney-specific conditional knockout mice: Wdr19-knockout (Wdr19-KO, Wdr19 f/-::Cdh16-Cre Tg/0), Pkd1-knockout (Pkd1-KO, Pkd1 f/-::Cdh16-Cre Tg/0), and Wdr19/Pkd1-double knockout (Wdr19&Pkd1-dKO, Wdr19 f/-;Pkd1 f/-::Cdh16-Cre Tg/0) mice. Ultrastructural analysis using transmission electron ... tara jlptWebJun 28, 2024 · Cdh16-Cre-: HDAC4 fl/fl (HDAC4-WT) and Cdh16-Cre +: HDAC4 fl/fl (HDAC4-KO) mice were killed 7 days after sham operation or UUO. (A) Micrographs of vimentin and p-Histone H3(Ser10) immunofluorescence staining; box at the lower right of vimentin/WT/UUO is a micrograph twice the size of the original partial position (Original … tarajmeh

"http://www.informatics.jax.org/allele/MGI:3641108 " - Cdh16-cre

Cdh16-cre

Epithelial-specific Cre/lox recombination in the …

Web012237 B6.Cg-Tg(Cdh16-cre)91Igr/J These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may … WebSep 26, 2016 · (A) Tfeb, Cyclin D1, Myc and Axin2 mRNA levels in kidneys from Cdh16 Cre and Cdh16 Cre::Tfeb fs mice treated with vehicle or PKF118-310. Values are shown as …

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WebSep 26, 2016 · Morphological analyses were performed on Cdh16 Cre and Cdh16 Cre::Tfeb fs, and on tam-treated Cdh16 CreErt2 and Cdh16 CreErt2::Tfeb fs mice. (A) Representative images of the abdominal cavity at P90.(B) Kidney size at different stages (p=days post-natal).(C) Relative ratio of kidney-to-body weight (KW/BW).Data from … WebKsp-cadherin is a unique, tissue-specific member of the cadherin family of cell adhesion molecules that is expressed in tubular epithelial cells in the kidney and developing …

WebIn aged Cdh16-Cre;Sav1(fl/fl) mice, we observed focal disruption of proximal tubules and perivascular lymphocytic infiltration. In conclusion, Sav1 is required for the maintenance … WebThe Township of Fawn Creek is located in Montgomery County, Kansas, United States. The place is catalogued as Civil by the U.S. Board on Geographic Names and its elevation …

WebTo this end a 1.4-kb promoter fragment of the kidney-specific cadherin gene (KspCad) was cloned upstream of a tamoxifen-inducible Cre recombinase (CreER(T2)) encoding sequence. Expression and activity of Cre was evaluated using reverse transcriptase polymerase chain reaction (RT-PCR) analysis and by crossbreeding to Z/EG reporter mice. WebJul 1, 2002 · In addition, since cdh16 cre is only expressed in collecting ducts and part of proximal tubules (Shao et al., 2002a; Shao et al., 2002b), HDAC4 may contribute to the aforementioned responses due ...

WebAug 1, 2002 · We took advantage of well-characterized Cdh16 Cre mice, in which the Cre recombinase is expressed in the epithelial lining of proximal tubules, collecting ducts, loops of Henle, and distal tubules ...

WebAt Quality Farm Supply, we strive to be “The Go-To Source for the Get-Go Farmer.” Whether you need parts for production agriculture, farm supplies, or tractor parts, our … t-ara jiyeon number 9WebMay 15, 2024 · By breeding with cdh16-Cre transgene mice, in which Cre expression is limited to the renal tubules, including Bowman’s capsule, proximal tubule, loop of Henle, distal tubule, and the collecting duct, we … tara jogger pantsWebTg (Cdh16-cre/ERT2)F427Djmp. Mutation details : The transgene consists of 1.4 kb fragment of the murine Cdh16 5' promoter region and a tamoxifen-inducible form of cre recombinase. Inducible Cre activity is seen in renal tubular epithelial cells and collecting ducts. ( J:110146 ) tarajo hanrahan muskegon miWebMar 1, 2024 · Cdh16 (Cadherin16, or Ksp-cadherin) is strongly expressed in epithelia of nephron tubules and collecting ducts in rabbit, mouse and human. Transgenic mice with … tara joseph amchamWebKsp1.3-Cre, Ksp1.3/Cre, KspCre, Ksp Cre, Ksp-Cre Molecular description: The transgene consists of 1341 bp of the Cdh16 5' flanking region, a beta-globin minimal promoter, and a cre recombinase sequence. The Cdh16 promoter was used to drive transgene expression in the developing kidney and genitourinary tract. Find mice (IMSR): tara joseph hong kong tara jubertWebMar 16, 2015 · CDH16-Cre transgenic mice, which express Cre recombinase under the cadherin 16 (CDH16) promoter specifically in adult renal tubules and developing genitourinary tract , were crossed with mice carrying floxed (f) alleles of Flcn, Fnip1, and Fnip2 to inactivate those genes. tara jp