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WebJan 24, 2007 · Chromosome territories. The natural habitat of eukaryotic genomes is the cell nucleus, where each chromosome is confined to a discrete region, referred to as a chromosome territory. This spatial ... WebSep 24, 2024 · Tom Misteli offers an update on how our view of genome organization has changed since his classic 2007 review. Principles of heterogeneity and stochasticity, polymer-polymer interactions, chromatin dynamics, phase separation, and architectural elements frame the updated model. WebJul 1, 2008 · The proposal that the spatial proximity of partners influences translocation outcome assumes the contact-first model. If broken chromosomes were able to roam the nucleus freely, the determining role of the spatial position of a broken genome region would likely be neutralized by the positional change of the broken chromosome end. fashams and mashams