WebNov 23, 2024 · Since its discovery, cisplatin has become the key drug in chemotherapy for cancers. Nevertheless, chemoresistance in cancers has become an impediment in using cisplatin for cancer treatment. The resistance toward cisplatin is multifaceted as it involves multiple cellular pathways. Ever since the knowledge of long noncoding RNAs as … WebApr 11, 2024 · Founded in December 2012, Junshi Biosciences (HKEX: 1877; SSE: 688180) is an innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of ...
Special Issue "Metabolomics in Drug Discovery and Development"
The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli (E. coli) bacteria. Although bacterial cell growth continued, cell division … WebMay 1, 2006 · Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its … canon dr-m260 roller kit
Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions
WebThe initial discovery was quite serendipitous. Rosenberg was looking into the effects of an electric field on the growth of bacteria. He noticed that bacteria ceased to divide when placed in an electric field and eventually traced the cause of this phenomenon to the platinum electrode he was using. [2] WebCisplatin-based chemotherapy is the standard of care for patients with muscle-invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, although molecular determinants of cisplatin response are incompletely understood. WebThe Italian chemist Michele Peyrone (1813–1883) was the first to synthesise cisplatin (cis-diamminedichloroplatinum (II)), the basis of today's most widely used family of anticancer … canon drop-in clear filter a