WebDominant-negative mutations. A third way by which protein misfolding can cause disease is through a dominant-negative mechanism, which occurs when a mutant protein antagonizes the function of the wild-type (WT) protein, causing a loss of protein activity even in a heterozygote (see poster panel 4). WebWhen Carl Raymond Cupples was born on 25 January 1905, in New York, United States, his father, Paul Vincent Cupples, was 21 and his mother, Catherine Cupples, was 23. He had at least 1 daughter with Elizabeth Tanyi. He lived in Lackawanna, Erie, New York, United States for about 30 years. He died on 15 June 1980, in Hamburg, ...
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