Tīmeklisrelapse. In this prospective study, we aimed to determine whether MRD-guided pre-emptive treatment with azacitidine could prevent relapse in these patients. Methods … Tīmeklis2024. gada 8. dec. · We report on the results of the RELAZA2 trial (ClinicalTrials.gov NCT01462578) by the Study Alliance Leukemia (SAL) group evaluating azacitidine …
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Tīmeklis2024. gada 7. dec. · We report on the results of the RELAZA2 trial (ClinicalTrials.gov NCT01462578) by the Study Alliance Leukemia (SAL) group evaluating azacitidine … Tīmeklis2024. gada 5. marts · The aim of this study was performed a retrospective multicenter study to evaluate the prognostic value of MRD by second generation of MFC among patients undergoing HSCT, using recommendations from the Euroflow consortium. MRD levels prior to transplantation significantly influenced outcomes irrespective of the … fresh eggs vs store bought eggs nutrition
Prospective phase II study of preemptive chimerism-driven …
Tīmeklis2024. gada 5. marts · The phase 2 RELAZA2 trial evaluated the role of hypomethylation agent azacitidine in minimal residual disease (MRD)-guided pre-emptive therapy to prevent or delay relapse in patients with myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML) after chemotherapy and allogenic stem cell transplantation. Tīmeklis2024. gada 1. jūn. · The findings of this RELAZA2 study demonstrate that MRD monitoring can identify patients who are likely to relapse and that MRD-guided treatment with a hypomethylating agent could be an effective strategy to prevent or substantially delay relapse with an acceptable safety profile in MRD-positive patients with AML. Tīmeklis2024. gada 10. jūl. · In a follow-up multicenter phase 2 study (RELAZA2), patients were prospectively monitored for the development of MRD after the completion of chemotherapy or allogeneic HCT if they had an appropriate and sensitive marker (ie, mutated NPM1, leukemia-specific fusion genes, or donor chimerism by flow cytometry). fresh eggs nutrition facts usda