Sialic acid acetylesterase
WebMar 21, 2024 · SIAE (Sialic Acid Acetylesterase) is a Protein Coding gene. Diseases associated with SIAE include Autoimmune Disease 6 and Autoimmune Disease. Gene … The enzyme sialate O-acetylesterase (EC 3.1.1.53) catalyzes the reaction ... "High performance liquid chromatography of enzymes of sialic acid metabolism". Hoppe-Seyler's Z. Physiol. Chem. 363: 1039–1040. This page was last edited on 16 August 2024, at 15:45 (UTC). Text is available under the Creative … See more The enzyme sialate O-acetylesterase (EC 3.1.1.53) catalyzes the reaction N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate In human it is encoded by the SIAE gene located on See more The SIAE gene contains 15 exons and expresses a protein that is approximately 56 kDa in size. It is known to be expressed in the adult See more SIAE activity negatively regulates B lymphocyte antigen receptor signalling and is required for the maintenance of immunological tolerance. It down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for See more Genetic defects in SIAE have been associated with multiple autoimmune diseases. Loss of function mutations in SIAE are much more frequently found in humans with See more
Sialic acid acetylesterase
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WebEsterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance Shiv Pillai, Annaiah Cariappa and Stephan P. Pirnie Cancer … WebJun 29, 2024 · Here, we focused on modulating 9-O and 7, 9-O-acetylation of Neu5Ac, via CRISPR-Cas9 gene editing, a functional group that is absent from Sias on many types of …
http://www.cazy.org/Carbohydrate-Esterases WebJun 19, 2024 · Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of vertebrates as well as cells of certain types of invertebrates and …
WebMay 28, 2015 · sialic acid-specific 9-O-acetylesterase and RNA expression in cells of hematopoietic and non-hematopoietic origin. Nucleic acids research, 24:4003-4008. … WebMar 3, 2024 · The sialic acid concentration in culture supernatants was consistent with the growth profiles of pneumococcal strains. ... Rott R, Klenk HD, Muller HP, Shukla AK, …
WebDocument: Group 2 coronaviruses encode an accessory envelope glycoprotein species, the hemagglutinin esterase (HE), which possesses sialate-O-acetylesterase activity and …
WebMar 1, 2001 · Sialate O-acetylesterase. Gene. SIAE. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 523. Protein ... Catalyzes the removal of … daily herald addison ilWebSialic Acid Acetylesterase is also known as H-Lse, SIAE, Sialate O-acetylesterase, Yolk sac protein 2, YSG2 . Open Advanced Filter 7 Applications, 4 Species currently selected. OR … bioinformatics bscWebMay 25, 2024 · Using reverse transcription-polymerase chain reaction to distinguish the two forms of message, we show that although the lysosomal sialic acid-specific 9-O-acetylesterase message has a widespread ... bioinformatics cairo universityWebModification of sialic acids with O-acetyl esters is known to protect mucin glycans from degradation by bacterial sialidases. Compared to SiaBb2, SiaBb1 has an additional O … daily herald archiveWebAcetyl esterase, sialate-O-acetylesterase. The LudgerZyme Acetyl Esterase Kit removes 9-, 8- and 7-O-acetyl groups from released sialic acids, released glycans or glycoproteins. It … bioinformatics byuWebPredicted to enable sialate O-acetylesterase activity. Predicted to be involved in carbohydrate metabolic process and regulation of immune system process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human SIAE (sialic acid acetylesterase). [provided by Alliance of Genome … daily herald archives freeWebNov 22, 2024 · Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature. Jul 2010 Functionally defective, rare, non-synonymous, germ-line, … daily herald archives